(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

Base Information

Chemical Name:(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)
CAS No.:1186527-18-3
Molecular Formula:C₄₀H₂₈N₄O₂₃S₄
Molecular Weight:1060.94
Hs Code.:

Synonyms:(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

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Chemical Property of (2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

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Technology Process of (2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

There total 6 articles about (2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1186527-32-1
(2R,3R)-2-(3-hydroxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

: 1186527-18-3
(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

Guidance literature:: In diethyl ether; acetonitrile; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.05.111

Reference yield:

: 1186527-14-9
(2R,3R)-2-(3,4-dihydroxy-5-(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxychromane-5,7-diyl bis(2-nitrobenzenesulfonate)

: 1186527-18-3
(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 3 h / -20 °C / Inert atmosphere

2: triethylamine / acetonitrile / -20 °C / Inert atmosphere

3: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere

4: acetonitrile; diethyl ether / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1038/ja.2016.14

Reference yield:

: 1186527-15-0
(2R,3R)-2-(3-tert-butyldiphenylsilyloxy-4-hydroxy-5-(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxychromane-5,7-diyl bis(2-nitrobenzenesulfonate)

: 1186527-18-3
(2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / -20 °C / Inert atmosphere

2: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere

3: acetonitrile; diethyl ether / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1038/ja.2016.14