methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

Base Information

Chemical Name:methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate
CAS No.:1289085-60-4
Molecular Formula:C₂₁H₂₄N₂O₅S
Molecular Weight:416.498
Hs Code.:

Synonyms:methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

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Chemical Property of methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

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Technology Process of methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

There total 3 articles about methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 814-68-6,25189-84-8
acryloyl chloride

: 543745-58-0
N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine

: 1289085-60-4
methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

Guidance literature:: glycine ethyl ester hydrochloride; acryloyl chloride; With potassium carbonate; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 1h;

N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine; With palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; toluene; at 120 ℃; for 16h; Inert atmosphere; Autoclave;
DOI:10.1002/ejoc.201001621

Reference yield:

: 65185-58-2
2-(2-bromophenyl)ethanamine

: 1289085-60-4
methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

2.2: 16 h / 120 °C / Inert atmosphere; Autoclave

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; 2.2: Heck-aza-Michael reaction;
DOI:10.1002/ejoc.201001621

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1289085-60-4
methyl (R,S)-2-(2-(2-p-tosyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; toluene / 1 h / 20 °C

2.2: 16 h / 120 °C / Inert atmosphere; Autoclave

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; 2.2: Heck-aza-Michael reaction;
DOI:10.1002/ejoc.201001621