2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

Base Information

Chemical Name:2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol
CAS No.:912959-54-7
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

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Technology Process of 2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

There total 11 articles about 2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 912959-25-2
(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

: 912959-54-7
2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

Guidance literature:: With potassium hydroxide; In methanol; water; at 18 ℃; for 1h;
DOI:10.1071/CH05181

Reference yield:

: 912959-22-9
(+/-)-1-ethyl-2-cyclohexene-1-ethanol acetate

: 912959-54-7
2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / chromium(IV) oxide; 3,5-dimethylpyrazole / CH₂Cl₂ / 8 h / -20 - -10 °C

2: 83 percent / pyridine; iodine / CCl₄ / 60 h / 18 °C

3: 81 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 2 h / 70 °C

4: 63 percent / p-TsOH / benzene / 22 h / 80 °C

5: 100 percent / KOH / methanol; H₂O / 1 h / 18 °C

With pyridine; 3,5-dimethyl-1H-pyrazole; potassium hydroxide; chromium (VI) oxide; iodine; copper; toluene-4-sulfonic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1071/CH05181

Reference yield:

: 912959-23-0
(+/-)-4-[2-(acetyloxy)ethyl]-4-ethyl-2-cyclohexen-1-one

: 912959-54-7
2-[8-ethyl-6-(2-nitro-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-8-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / pyridine; iodine / CCl₄ / 60 h / 18 °C

2: 81 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 2 h / 70 °C

3: 63 percent / p-TsOH / benzene / 22 h / 80 °C

4: 100 percent / KOH / methanol; H₂O / 1 h / 18 °C

With pyridine; potassium hydroxide; iodine; copper; toluene-4-sulfonic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; tetrachloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1071/CH05181