(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

Base Information

Chemical Name:(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate
CAS No.:912959-25-2
Molecular Formula:C₂₀H₂₅NO₆
Molecular Weight:375.422
Hs Code.:

Synonyms:(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

Chemical Property:

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Technology Process of (+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

There total 10 articles about (+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 912959-24-1
(+/-)-4-[2-(acetyloxy)ethyl]-4-ethyl-2-(2-nitrophenyl)-2-cyclohexen-1-one

: 107-21-1
ethylene glycol

: 912959-25-2
(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

Guidance literature:: With toluene-4-sulfonic acid; In benzene; at 80 ℃; for 22h;
DOI:10.1071/CH05181

Reference yield:

: 912959-22-9
(+/-)-1-ethyl-2-cyclohexene-1-ethanol acetate

: 912959-25-2
(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / chromium(IV) oxide; 3,5-dimethylpyrazole / CH₂Cl₂ / 8 h / -20 - -10 °C

2: 83 percent / pyridine; iodine / CCl₄ / 60 h / 18 °C

3: 81 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 2 h / 70 °C

4: 63 percent / p-TsOH / benzene / 22 h / 80 °C

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium (VI) oxide; iodine; copper; toluene-4-sulfonic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1071/CH05181

Reference yield:

: 912959-23-0
(+/-)-4-[2-(acetyloxy)ethyl]-4-ethyl-2-cyclohexen-1-one

: 912959-25-2
(+/-)-8-ethyl-6-(2-nitrophenyl)-1,4-dioxaspiro[4.5]dec-6-ene-8-ethanol acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / pyridine; iodine / CCl₄ / 60 h / 18 °C

2: 81 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 2 h / 70 °C

3: 63 percent / p-TsOH / benzene / 22 h / 80 °C

With pyridine; iodine; copper; toluene-4-sulfonic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrachloromethane; dimethyl sulfoxide; benzene;
DOI:10.1071/CH05181