(R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene

Base Information

• Chemical Name: (R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene
• CAS No.: 294847-71-5
• Molecular Formula: C₁₅H₂₀O₃S
• Molecular Weight: 280.388
• Mol file: 294847-71-5.mol

Synonyms:(R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene

Chemical Property of (R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene

There total 2 articles about (R_S,R_C)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.2%

vinyl acetate (108-05-4,9003-20-7) + (E)-4-Methyl-1-((R)-toluene-4-sulfinyl)-pent-1-en-3-ol (294858-19-8) → (RS,SC)-(E)-4-methyl-1-(p-tolylsulfinyl)-1-penten-3-ol (169125-80-8) + (RS,RC)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene (294847-71-5)

Guidance literature:

With 4 A molecular sieve; lipase; In di-isopropyl ether; at 20 ℃; for 240h;

DOI:10.1016/S0957-4166(00)00257-3

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + (SS,SS)-1,1-bis(p-tolylsulfinyl)methane (59532-34-2) + isovaleraldehyde (590-86-3) → (RS,SC)-(E)-4-methyl-1-(p-tolylsulfinyl)-1-penten-3-ol (169125-80-8) + (RS,RC)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene (294847-71-5)

Guidance literature:

(S_S,S_S)-1,1-bis(p-tolylsulfinyl)methane; isovaleraldehyde; With piperidine; In acetonitrile;

vinyl acetate; With molecular sieve; Lipase PS; In di-isopropyl ether;

DOI:10.1016/S0957-4166(01)00189-6

Reference yield: 71.0%

malonic acid dimethyl ester (108-59-8) + (RS,RC)-(E)-3-acetoxy-4-methyl-1-(p-tolylsulfinyl)-1-pentene (294847-71-5) → methyl (RS,SC)-(E)-2-methoxycarbonyl-3-iso-propyl-5-(p-tolylsulfinyl)-4-pentenoate

Guidance literature:

With sodium hydride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; at 70 ℃; for 12h;

DOI:10.1016/S0957-4166(01)00189-6

upstream raw materials:

vinyl acetate

(E)-4-Methyl-1-((R)-toluene-4-sulfinyl)-pent-1-en-3-ol

(S_S,S_S)-1,1-bis(p-tolylsulfinyl)methane

isovaleraldehyde