N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

Base Information

Chemical Name:N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine
CAS No.:51549-41-8
Molecular Formula:C₂₉H₄₅N₅O₄Si₂
Molecular Weight:583.878
Hs Code.:

<i>N</i><sup>6</sup>-benzoyl-<i>O</i><sup>3'<sub>,<i>O</i></sub>5'</sup>-bis-(<i>tert</i>-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

Synonyms:N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

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Chemical Property of N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

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Technology Process of N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

There total 6 articles about N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898253-79-7
8-bromo-N₅-benzoyl-O₃',O₅'-bis(tert-butyldimethylsilyl)-2'-deoxyadenosine

: (5'S)-N₅-benzoyl-O₃',O₅'-bis(tert-butyldimethylsilyl)-5',8-cyclo-2'-deoxyadenosine

: (5'R)-N₅-benzoyl-O₃',O₅'-bis(tert-butyldimethylsilyl)-5',8-cyclo-2'-deoxyadenosine

: 51549-41-8
N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

Guidance literature:: With air; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In acetonitrile; at 90 ℃; for 2h;
DOI:10.1021/jo060197z

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 51549-41-8
N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole; (dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C

2: 60 percent / pyridine / 20 °C

3: 33 percent Turnov_. / tris(trimethylsilyl) silane; AIBN; air / fluorobenzene / 2 h / 90 °C

With pyridine; 1H-imidazole; dmap; air; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In fluorobenzene; N,N-dimethyl-formamide;
DOI:10.1021/jo060197z

Reference yield:

: 14985-44-5,90968-89-1
8-bromo-2'-deoxyadenosine

: 51549-41-8
N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole; (dimethylamino)pyridine / dimethylformamide / 3 h / 20 °C

2: 60 percent / pyridine / 20 °C

3: 33 percent Turnov_. / tris(trimethylsilyl) silane; AIBN; air / fluorobenzene / 2 h / 90 °C

With pyridine; 1H-imidazole; dmap; air; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In fluorobenzene; N,N-dimethyl-formamide;
DOI:10.1021/jo060197z