2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI)

Base Information

Chemical Name:2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI)
CAS No.:255883-13-7
Molecular Formula:C₆H₆F₃NO₃
Molecular Weight:197.114
Hs Code.:
Mol file:255883-13-7.mol

Synonyms:2-Azetidinecarboxylicacid, 1-(trifluoroacetyl)-, (2R)- (9CI)

Suppliers and Price of 2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI)

There total 2 articles about 2-Azetidinecarboxylic acid, 1-(trifluoroacetyl)-, (2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 383-63-1
ethyl trifluoroacetate,

: 2133-34-8,20063-89-2
(2S)-azetidine-2-carboxylic acid

: 255882-90-7,255883-13-7
(S)-1-(2,2,2-trifluoroacetyl)azetidine-2-carboxylic acid

Guidance literature:: With diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 18h;

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 7729-30-8,20063-89-2
(R)-azetidine-2-carboxylic acid

: 255883-13-7
C₆H₆F₃NO₃

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 16h;
DOI:10.1021/jacs.7b06994

Reference yield:

: 255882-90-7,255883-13-7
(S)-1-(2,2,2-trifluoroacetyl)azetidine-2-carboxylic acid

: C₂₇H₂₀F₃N₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 0 °C

2: palladium diacetate; phosphoric acid dibenzyl ester; silver(I) acetate / 1,2-dichloro-ethane / 24 h / 110 °C / Inert atmosphere

With phosphoric acid dibenzyl ester; silver(I) acetate; palladium diacetate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.7b06994