5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine

Base Information

• Chemical Name: 5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine
• CAS No.: 110142-94-4
• Molecular Formula: C₅₀H₄₅N₅O₆
• Molecular Weight: 811.937

Synonyms:5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine

Chemical Property of 5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine

Chemical Property:

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Technology Process of 5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine

There total 3 articles about 5'-O-(4-methoxyphenyl)diphenylmethyl-N⁶-(4-methoxyphenyl)diphenylmethyl-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

mono-4-methoxytrityl chloride (14470-28-1) + adenosine (58-61-7) → 5'-O-(4-methoxyphenyl)diphenylmethyl-N6-(4-methoxyphenyl)diphenylmethyl-adenosine (110142-94-4)

Guidance literature:

With pyridine; at 50 ℃;

DOI:10.1021/jm00394a034

Reference yield:

3'-O-(acetyloxymethyl)adenosin-2'-yl adenosin-5'-yl 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphate (1259402-79-3) → 5'-O-(4-methoxyphenyl)diphenylmethyl-N6-(4-methoxyphenyl)diphenylmethyl-adenosine (110142-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hog liver carboxyesterase; water; sodium chloride / 37 °C / pH 7.5 / HEPES buffer; Enzymatic reaction

2: pyridine / 35 °C

With pyridine; hog liver carboxyesterase; water; sodium chloride;

DOI:10.1002/cbdv.201000288

Reference yield:

3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl adenosin-5'-yl 3'-O-(pivaloyloxymethyl)adenosin-2'-yl phosphate (1259402-83-9) → 5'-O-(4-methoxyphenyl)diphenylmethyl-N6-(4-methoxyphenyl)diphenylmethyl-adenosine (110142-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hog liver carboxyesterase; water; sodium chloride / 24 h / 37 °C / pH 7.5 / HEPES buffer; Enzymatic reaction

2: pyridine / 35 °C

With pyridine; hog liver carboxyesterase; water; sodium chloride;

DOI:10.1002/cbdv.201000288

upstream raw materials:

mono-4-methoxytrityl chloride

adenosine

3'-O-(acetyloxymethyl)adenosin-2'-yl adenosin-5'-yl 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphate

3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl adenosin-5'-yl 3'-O-(pivaloyloxymethyl)adenosin-2'-yl phosphate

Downstream raw materials:

3'-O-p-tolylsulphonyladenosine

Toluene-4-sulfonic acid (2R,3S,4R,5R)-4-hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester

5'-O,N₆-bis(4-methoxytrityl)-3'-O-pivaloyladenosine

2'-O-(pivaloyloxymethyl)-5'-O,N⁶-bis(4-methoxytrityl)adenosine

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