(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Name:(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate
CAS No.:1260174-17-1
Molecular Formula:C₄₃H₆₃N₅O₅Si₂
Molecular Weight:786.175
Hs Code.:

(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Synonyms:(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Property of (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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Technology Process of (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

There total 17 articles about (Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

: 64724-29-4
tributyl-((Z)-2-ethoxy-vinyl)-stannane

: 1260174-17-1
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1260174-17-1
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 50 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 18 h / 20 °C

3.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

4.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere; Sealed tube

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

7.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

With potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil; 8.1: Stille Coupling;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1260174-17-1
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 15 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

2.1: tetrahydrofuran / 20 °C / Inert atmosphere; Sealed tube

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere; Sealed tube

4.1: 3 h / 100 °C / Neat (no solvent)

5.1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / 20 °C

5.2: 0 °C

6.1: ammonia / methanol / 18 h / 100 °C / Sealed tube

7.1: hydrogenchloride; water / 1,4-dioxane; ethanol / 80 °C / Sealed tube

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 50 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

9.2: 18 h / 20 °C

10.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

11.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

12.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere; Sealed tube

13.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

14.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

15.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; lithium hydroxide monohydrate; ammonia; water; hydrogen; sodium hydride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil; 15.1: Stille Coupling;