ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Name:ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate
CAS No.:1260106-52-2
Molecular Formula:C₂₉H₂₉N₅O₂
Molecular Weight:479.582
Hs Code.:

Synonyms:ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

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Chemical Property of ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

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Technology Process of ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

There total 17 articles about ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260174-17-1
(Z)-ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(2-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

: 1260106-52-2
ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: With water; trifluoroacetic acid;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1260106-52-2
ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 16 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

2.1: tetrahydrofuran / 20 °C / Inert atmosphere; Sealed tube

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere; Sealed tube

4.1: 3 h / 100 °C / Neat (no solvent)

5.1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / 20 °C

5.2: 0 °C

6.1: ammonia / methanol / 18 h / 100 °C / Sealed tube

7.1: hydrogenchloride; water / 1,4-dioxane; ethanol / 80 °C / Sealed tube

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 50 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

9.2: 18 h / 20 °C

10.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

11.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

12.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere; Sealed tube

13.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

14.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

15.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

16.1: trifluoroacetic acid; water

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; lithium hydroxide monohydrate; ammonia; water; hydrogen; sodium hydride; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil; 15.1: Stille Coupling;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1260106-52-2
ethyl 2-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 17 steps

1.1: toluene-4-sulfonic acid / benzene / Reflux

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

3.1: tetrahydrofuran / 20 °C / Inert atmosphere; Sealed tube

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere; Sealed tube

5.1: 3 h / 100 °C / Neat (no solvent)

6.1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / 20 °C

6.2: 0 °C

7.1: ammonia / methanol / 18 h / 100 °C / Sealed tube

8.1: hydrogenchloride; water / 1,4-dioxane; ethanol / 80 °C / Sealed tube

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 50 °C

10.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

10.2: 18 h / 20 °C

11.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 18 h / Inert atmosphere; Sealed tube

12.1: N-iodo-succinimide / acetonitrile / 18 h / 20 °C

13.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere; Sealed tube

14.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

15.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

16.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

17.1: trifluoroacetic acid; water

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; lithium hydroxide monohydrate; ammonia; water; hydrogen; sodium hydride; toluene-4-sulfonic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil; benzene; 16.1: Stille Coupling;