5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Base Information

Chemical Name:5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄
CAS No.:190143-66-9
Molecular Formula:C₄₈H₇₀O₉Si
Molecular Weight:819.164
Hs Code.:

5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A<sub>4</sub>

Synonyms:5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Suppliers and Price of 5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Chemical Property:

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Technology Process of 5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

There total 6 articles about 5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 36293-05-7
2-methyl-2-phenylpropanoyl chloride

: 141548-05-2
5-O-t-butyldimethylsilyl-24a-hydroxymilbemycin A₄

: 190143-66-9
5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1271/bbb.61.806

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190143-66-9
5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaBH₄, 2) imidazole / 1) MeOH, 0 deg C, 20 min, 2) DMF, room temperature, 2 h

2: 89 percent / n-BuNH₂, PPh₃, formic acid / Pd(PPh₃)4 / tetrahydrofuran / 0.67 h / Ambient temperature

3: 54 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; formic acid; N-butylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1271/bbb.61.806

Reference yield:

: 123022-52-6
30-Hydroxymilbemycin A₄

: 190143-66-9
5-O-t-butyldimethylsilyl-24a-(2-methyl-2-phenylpropionyloxy)milbemycin A₄

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / MnO₂ / CH₂Cl₂ / 3 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 1) NaBH₄, 2) imidazole / 1) MeOH, 0 deg C, 20 min, 2) DMF, room temperature, 2 h

4: 89 percent / n-BuNH₂, PPh₃, formic acid / Pd(PPh₃)4 / tetrahydrofuran / 0.67 h / Ambient temperature

5: 54 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; formic acid; N-butylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1271/bbb.61.806