4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine

Base Information

• Chemical Name: 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine
• CAS No.: 762172-76-9
• Molecular Formula: C₁₉H₁₇FN₆
• Molecular Weight: 348.383

Synonyms:4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine

Chemical Property of 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine

Chemical Property:

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Technology Process of 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine

There total 1 articles about 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]ethylamine (762172-95-2) → 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine (762172-76-9)

Guidance literature:

With ammonia; In tetrahydrofuran; at 20 ℃; for 12h; under 1810.07 - 2585.81 Torr;

DOI:10.1016/j.ejmech.2007.09.013

Reference yield: 63.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-[7-(2-aminoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-ylamine (762172-76-9) → C21H21FN6 (762172-77-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2007.09.013

upstream raw materials:

2-[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]ethylamine

Downstream raw materials:

C₂₁H₂₁FN₆

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