2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Base Information

• Chemical Name: 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone
• CAS No.: 131523-29-0
• Molecular Formula: C₂₃H₁₉NO₂
• Molecular Weight: 341.409
• Mol file: 131523-29-0.mol

Synonyms:2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property of 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

There total 10 articles about 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C16H13NO2 + benzaldehyde (100-52-7) → 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-29-0)

Guidance literature:

With trichlorosilane; C₁₅H₁₆N₂O₄S; In dichloromethane; Inert atmosphere;

Reference yield: 27.0%

2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-26-7) → 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-29-0)

Guidance literature:

With aluminum tri-bromide; In chlorobenzene; at 95 ℃; for 2h;

DOI:10.1248/cpb.47.529

Reference yield:

4-[(1-hydroxy-3-oxo-1-phenethylisoindol-2-yl)methyl]phenyl acetate (1401522-30-2) → C23H19NO2 (1401522-48-2) + 2-(4-hydroxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone (131523-29-0)

Guidance literature:

With hydrogenchloride; In water; for 5h; Overall yield = 87 %; diastereoselective reaction; Reflux;

DOI:10.1016/j.tetlet.2012.07.142

upstream raw materials:

phenethylmagnesium bromide

2-(4-Hydroxybenzyl)isoindole-1,3-dione

2-(4-methoxybenzyl)-3-<(E)-2-phenylethylidene>-1-isoindolinone

2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione