(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

Base Information

Chemical Name:(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione
CAS No.:1400585-43-4
Molecular Formula:C₂₄H₃₁NO₂S₂Si
Molecular Weight:457.733
Hs Code.:

Synonyms:(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

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Technology Process of (S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

There total 4 articles about (S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 76186-04-4
(S)-4-isopropylthiazolidine-2-thione

: 93853-60-2
<(tert-butyldiphenylsilyl)oxy>acetyl chloride

: 1400585-43-4
(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

Guidance literature:: (S)-4-isopropylthiazolidine-2-thione; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

<(tert-butyldiphenylsilyl)oxy>acetyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.58333h; Inert atmosphere;
DOI:10.1002/ejoc.201901097

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1400585-43-4
(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide; water / methanol; tetrahydrofuran / 3 h / 0 °C

3.1: oxalyl dichloride / benzene / 1 h / Inert atmosphere; Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

4.2: 1.58 h / -78 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; oxalyl dichloride; water; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene;
DOI:10.1002/ejoc.201901097

Reference yield:

: 154698-92-7
methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate

: 1400585-43-4
(S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / methanol; tetrahydrofuran / 3 h / 0 °C

2.1: oxalyl dichloride / benzene / 1 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.58 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; water; potassium hydroxide; In tetrahydrofuran; methanol; hexane; benzene;
DOI:10.1002/ejoc.201901097