76186-04-4

Usage

Uses

Used in Pharmaceutical Industry:
(S)-4-ISOPROPYLTHIAZOLIDINE-2-THIONE is used as an antiviral agent for its potential to combat viral infections by interfering with viral replication mechanisms.
(S)-4-ISOPROPYLTHIAZOLIDINE-2-THIONE is used as an antidiabetic agent for its potential to improve glucose metabolism by inhibiting the enzyme DPP-4, which plays a crucial role in the regulation of blood glucose levels.
(S)-4-ISOPROPYLTHIAZOLIDINE-2-THIONE is used as an antioxidant for its potential to protect cells from oxidative damage, which can contribute to various diseases and aging.
(S)-4-ISOPROPYLTHIAZOLIDINE-2-THIONE is used as an anti-inflammatory agent for its potential to reduce inflammation, which is a common factor in many chronic diseases and conditions.

Upstream product

• 75-15-0 carbon disulfide 
• 2026-48-4 (S)-valinol 
• 42163-70-2 4-isopropyl-1,3-thiazolidine-2-thione 
• 102831-92-5 (4S)-4-isopropyl-3-(1-oxopropyl)-1,3-thiazolidine-2-thione 
• 137032-32-7 α-methyl-trans-cinnamaldehyde dimethyl acetal 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 332902-42-8 (4S)-N-[(2R,3S,4E)-2,4-dimethyl-3-methoxy-5-phenyl-4-pentenoyl]-4-isopropyl-1,3-thiazolidine-2-thione 
• 375826-94-1 (E)-(3R,6S,7S)-7-Benzyloxy-3-hydroxy-1-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-6,8-dimethyl-non-4-en-1-one 

Downstream Products

• 124201-69-0 3-((phenylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 132288-45-0 3-(((4-methoxyphenyl)thio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 118554-25-9 (1S,2R)-2-((S)-4-Isopropyl-2-thioxo-thiazolidine-3-carbonyl)-cyclobutanecarboxylic acid methyl ester 
• 118554-25-9 (1R,2S)-2-((S)-4-Isopropyl-2-thioxo-thiazolidine-3-carbonyl)-cyclobutanecarboxylic acid methyl ester 
• 88335-95-9 (-)-(1S,5R)-3-oxabicyclo<3.2.0>heptan-2-one 
• 75658-85-4 (+)-(1S,5R)-cis-3-oxabicyclo<3.2.0>heptan-2-one 
• 124201-72-5 3-(2(R)-(5-oxo-2(S)-pyrrolidinyl)(phenylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 102831-92-5 (4S)-4-isopropyl-3-(1-oxopropyl)-1,3-thiazolidine-2-thione 
• 1400585-43-4 (S)-N-(2-tert-butyldiphenylsilyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione 
• 1400585-45-6 (S)-N-(2-benzoyloxyacetyl)-4-isopropyl-1,3-thiazolidine-2-thione 
• 132288-44-9 3-((cyclohexylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 

Relevant academic research and scientific papers

Synthesis of new C3 symmetric amino acid- and aminoalcohol-containing chiral stationary phases and application to HPLC enantioseparations

We recently reported a new C3-symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid-derived chiral high-performance liquid chromatography (HPLC) stationary phase (CSP 1) that demonstrated better results as compared to a previously described N-3,5-dintrobenzoyl (DNB) (R)-phenylglycinol-derived CSP. Over a decade ago, (S)-leucinol, (R)-phenylglycine, and (S)-leucine derivatives were used as the starting materials of 3,5-DNB-based Pirkle-type CSPs for chiral separation. In this study, three new C3-symmetric CSPs (CSP 2, 3, and 4) were prepared by combining the ideas and results mentioned above. Here we describe the synthetic procedures and applications of the new C3-symmetric CSPs (CSP 2–CSP 4).

Total synthesis of the polyene macrolide dermostatin A

Herein we provide full details of studies which culminated in the first total synthesis of the polyene macrolide dermostatin A, confirming our earlier stereochemical assignment. A highly convergent synthesis was developed, featuring the cyanohydrin acetonide method for polyol construction and a Stille approach to polyene introduction. The strategies and tactics developed en route should be of value for the preparation of other members of the polyene macrolide class, as well as analogs of the dermostatins.

Chelation-Controlled Chemo-, Regio- and Enantio-Selective Synthesis of Homoallylic Alcohols

Optically active allylic sulphides 10-13, bearing two different leaving groups, react with organocopper reagents by selective substitution of the heterocyclic moiety leading to optically active homoallylic pivalates with chemo-, regio- and enantio-control.This selectivity seems to be related to the coordination exerted by the heterocyclic nucleus towards the organometal.