Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 255735-88-7
• Molecular Formula: C8H18N2O2
• Molecular Weight: 174.243
• Hs Code.: 2924199090
• Mol file: 255735-88-7.mol

Synonyms:Carbamicacid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI);(2-Aminopropyl)carbamicacid tert-butyl ester;2-Amino-1-[[(1,1-dimethylethoxy)carbonyl]amino]propane;N-(2-Aminopropyl)carbamate tert-butyl ester;tert-Butyl(2-aminopropyl)carbamate;

Chemical Property of Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.454
• Boiling Point: 263.719 °C at 760 mmHg
• PKA: 12.51±0.46(Predicted)
• Flash Point: 113.293 °C
• PSA: 64.35000
• Density: 0.984g/cm³
• LogP: 1.94950
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DCM, Hexane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

(2-Aminopropyl)carbamicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2-Aminopropyl)carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of Misoprostol (M368755), an cytoprotective prostaglandin PGE analogue.

Technology Process of Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)

There total 9 articles about Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,2-diaminopropan (78-90-0,10424-38-1) → [(2R)-2-aminopropyl]carbamic acid,1,1-dimethylethyl ester (255735-88-7)

Guidance literature:

With thiourea; In toluene; at 60 - 70 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2008.03.138

Reference yield: 83.7%

1-(N-tert-butoxycarbonylamino)-2-azidopropane → [(2R)-2-aminopropyl]carbamic acid,1,1-dimethylethyl ester (255735-88-7)

Guidance literature:

With hydrogen; palladium over charcoal; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 70.0%

tert-butyl phenyl carbonate (6627-89-0) + 1,2-diaminopropan (78-90-0,10424-38-1) → [(2R)-2-aminopropyl]carbamic acid,1,1-dimethylethyl ester (255735-88-7)

Guidance literature:

In ethanol; Heating;

DOI:10.1055/s-2002-34859

upstream raw materials:

tert-Butyl 4-nitrophenyl carbonate

1,2-diaminopropan

tert-butyl phenyl carbonate

1-azido-2-(N-tert-butoxycarbonylamino)propane

Downstream raw materials:

3-[(2-benzyloxycarbonyl-ethyl)-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-amino]-propionic acid benzyl ester

tert-Butyl (2-{[7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}propyl)carbamate

tert-butyl [2-({[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)propyl]carbamate

tert-butyl (2-{[(4-ethoxyphenyl)carbonyl]amino}-propyl)carbamate

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