N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

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Chemical Name:N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide
CAS No.:1252602-02-0
Molecular Formula:C₅₀H₆₁N₇O₆
Molecular Weight:856.078
Hs Code.:

N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

Synonyms:N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

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Chemical Property of N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

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Technology Process of N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

There total 9 articles about N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1007877-77-1
(R)-2-phenyl-2-(pyrrolidin-1-yl)acetic acid

: 1252600-84-2
methyl (S)-3,3-dimethyl-1-oxo-1-((S)-2-(4-((phenyl(4-((S)-pyrrolidine-2-carboxamido)benzyl)amino)methyl)phenylcarbamoyl)pyrrolidin-1-yl)butan-2-ylcarbamate

: 1252602-02-0
N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 110392-56-8
bis(4-nitrobenzyl)phenylamine

: 1252602-02-0
N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: Raney Nickel; A-7000 / water; tetrahydrofuran / 2 h / 20 °C / 1551.49 Torr

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h

3: trifluoroacetic acid / dichloromethane / 0.75 h / Inert atmosphere

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 20 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 83215-18-3
4-aniline

: 1252602-02-0
N-(methoxycarbonyl)-3-methyl-L-valyl-N-[4-({phenyl[4-({1-[(2R)-2-phenyl-2-pyrrolidin-1-ylacetyl]-L-prolyl}amino)benzyl]amino}methyl)phenyl]-L-prolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h

2: trifluoroacetic acid / dichloromethane / 0.75 h / Inert atmosphere

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 20 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; dimethyl sulfoxide;