N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Base Information

Chemical Name:N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid
CAS No.:213773-01-4
Molecular Formula:C₂₈H₄₆N₂O₆
Molecular Weight:506.683
Hs Code.:

Synonyms:N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

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Chemical Property of N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

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Technology Process of N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

There total 9 articles about N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213772-85-1
[5-(benzyl-tert-butoxycarbonyl-amino)-pentyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester

: 213773-01-4
N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Guidance literature:: With sodium hypochlorite; sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In dichloromethane; at 0 ℃; for 5h; pH=8;
DOI:10.1080/15257770008035031

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 213773-01-4
N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂O; diethyl ether / 20 °C

2: NaBH₄ / ethanol / 0 - 20 °C

3: CH₂Cl₂ / 3 h / 20 °C

4: Et₃N / diethyl ether

5: K₂CO₃ / dimethylformamide / 6 h / 100 °C

6: CH₂Cl₂ / 3 h / 20 °C

7: aq. NaHCO₃; NaOCl; KBr / TEMPO; tricaprylylmethylammonium chloride / CH₂Cl₂ / 5 h / 0 °C / pH 8

With sodium hypochlorite; sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction / 3: Substitution / 4: Tosylation / 5: Substitution / 6: Substitution / 7: Oxidation;
DOI:10.1080/15257770008035031

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 213773-01-4
N-(N'-benzyl-N'-tert-butoxycarbonyl-5-aminopentyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: Et₃N / diethyl ether

3: K₂CO₃ / dimethylformamide / 6 h / 100 °C

4: CH₂Cl₂ / 3 h / 20 °C

5: aq. NaHCO₃; NaOCl; KBr / TEMPO; tricaprylylmethylammonium chloride / CH₂Cl₂ / 5 h / 0 °C / pH 8

With sodium hypochlorite; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Tosylation / 3: Substitution / 4: Substitution / 5: Oxidation;
DOI:10.1080/15257770008035031