Technology Process of N-(1-(1-benzyl-1H-1,2,3-triazol-4-yl)cyclohexyl)-3-methyl-[1,1'-biphenyl]-2-carboxamide
There total 4 articles about N-(1-(1-benzyl-1H-1,2,3-triazol-4-yl)cyclohexyl)-3-methyl-[1,1'-biphenyl]-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-{1-(1-benzyl-1H-1,2,3-triazol-4-yl)cyclohexyl}-2-methylbenzyamide; phenylmagnesium bromide;
With
iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; zinc dibromide;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
Schlenk technique;
With
1,2-bis-(diphenylphosphino)ethane;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
With
1,2-dichloro-2-methylpropane;
In
tetrahydrofuran;
at 55 ℃;
for 36h;
DOI:10.1002/anie.201311024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
3.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide; iron(III) chloride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique
3.2: 0.17 h / 20 °C
3.3: 36 h / 55 °C
With
iron(III) chloride; copper(ll) sulfate pentahydrate; N,N,N,N,-tetramethylethylenediamine; sodium L-ascorbate; triethylamine; zinc dibromide;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201311024
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide; iron(III) chloride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 0.17 h / 20 °C
2.3: 36 h / 55 °C
With
iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; triethylamine; zinc dibromide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201311024
