ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

Base Information

Chemical Name:ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt
CAS No.:1403338-25-9
Molecular Formula:C₂HF₃O₂*C₂₇H₂₈FNO₄
Molecular Weight:563.546
Hs Code.:

Synonyms:ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

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Chemical Property of ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

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Technology Process of ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

There total 7 articles about ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167073-19-0,172336-32-2,172336-33-3
(E)-(3R,5S)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester

: 1403338-25-9
ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

Guidance literature:: With trifluoroacetic acid; In ethyl acetate; at 0 - 30 ℃; Product distribution / selectivity;

Reference yield:

: 148901-68-2,121660-63-7
(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal

: 1403338-25-9
ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -35 - -15 °C

1.2: 1 h / -80 - -75 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 24 h / 20 - 30 °C

2.2: pH 1.5 - 2

2.3: 20 °C

3.1: hydrogenchloride; water / dichloromethane / 0 - 30 °C / pH 2 - 2.5

4.1: potassium iodide / N,N-dimethyl-formamide / 0.75 h / 25 - 65 °C / Inert atmosphere

4.2: 0.5 h / 60 - 65 °C

4.3: 0.5 h / 60 - 65 °C

5.1: dichloromethane / 3.25 h / 15 - 20 °C

6.1: zinc(II) oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere

6.2: 12 h

7.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C

8.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere

9.1: trifluoroacetic acid / ethyl acetate / 0 - 30 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; diethyl methoxy borane; water; trifluoroacetic acid; potassium iodide; zinc(II) oxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

: 1403338-25-9
ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate, trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere

2: trifluoroacetic acid / ethyl acetate / 0 - 30 °C

With methanol; sodium tetrahydroborate; diethyl methoxy borane; trifluoroacetic acid; In tetrahydrofuran; ethyl acetate;