6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-

Base Information

Chemical Name:6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-
CAS No.:254452-91-0
Molecular Formula:C27H26FNO4
Molecular Weight:447.506
Hs Code.:
Mol file:254452-91-0.mol

Synonyms:

Suppliers and Price of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-

Chemical Property:

Purity/Quality:: 98.0% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)-

There total 15 articles about 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-, ethyl ester, (5S,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1403338-24-8
ethyl (5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-5-(tert-butyldimethylsilyloxy)-3-oxo-6-heptenoate

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at -10 ℃; for 4h;

Reference yield:

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 155052-31-6
(S)‐N‐(1‐hydroxymethylisobutyl)(3,5‐di‐tert‐butylsalicylidene)

: 148901-68-2,121660-63-7
(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: (S)‐N‐(1‐hydroxymethylisobutyl)(3,5‐di‐tert‐butylsalicylidene); With titanium(IV) tetraethanolate; In dichloromethane; at 20 ℃; for 1h;

4-methyleneoxetan-2-one; (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal; In dichloromethane; at -50 ℃; for 22h;

With sodium hydrogencarbonate; at 20 ℃; for 2h;

Reference yield:

: C₃₃H₄₆FNO₄Si₂

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: C₃₃H₄₆FNO₄Si₂; With trifluoroacetic acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; ethyl acetate; for 0.0833333h; Product distribution / selectivity;