2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Base Information

Chemical Name:2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
CAS No.:1379453-58-3
Molecular Formula:C₂₃H₂₃ClN₄O₇S
Molecular Weight:534.977
Hs Code.:

Synonyms:2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

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Chemical Property of 2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

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Technology Process of 2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

There total 3 articles about 2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 150-60-7
dibenzyl disulphide

: 16321-99-6
2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

: 1379453-58-3
2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Guidance literature:: dibenzyl disulphide; 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

With isopentyl nitrite; In acetonitrile; at 60 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.03.047

Reference yield:

: 118-00-3
G

: 1379453-58-3
2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / acetonitrile / 0.5 h / 20 °C

2.1: tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / 1,2-dichloro-ethane; acetonitrile / Reflux

2.2: pH 7

3.1: acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.2: 6 h / 60 °C / Inert atmosphere

With dmap; tetraethylammonium chloride; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.ejmech.2012.03.047

Reference yield:

: 6979-94-8
2',3',5'-tri-O-acetyl-guanosine

: 1379453-58-3
2-benzylthio-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / 1,2-dichloro-ethane; acetonitrile / Reflux

1.2: pH 7

2.1: acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2.2: 6 h / 60 °C / Inert atmosphere

With tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.ejmech.2012.03.047