2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

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Chemical Name:2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide
CAS No.:1201986-89-1
Molecular Formula:C₃₄H₃₆N₄O₆S
Molecular Weight:628.749
Hs Code.:

Synonyms:2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

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Chemical Property of 2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

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Technology Process of 2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

There total 4 articles about 2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1201986-90-4
5-[1-(2-nitro-benzenesulfonylamino)-ethyl]-furan-2-carboxylic acid

: (R)-3-phenyl-1-(((2S,4R)-4-phenylpyrrolidin-2-yl)methyl)pyrrolidine dihydrochloride

: 1201986-89-1
2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 16h;

Reference yield:

: 1201986-77-7
(2S,4R)-tert-butyl-4-phenyl-2-((R)-3-phenylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

: 1201986-89-1
2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

1.2: 18 - 25 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 18 - 25 °C

With dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1201986-73-3
(2S,4R)-4-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

: 1201986-89-1
2-nitro-N-(1-(5-((2S,4R)-4-phenyl-2-(((R)-3-phenyprrolidin-1-yl)methyl)pyrrolidine-1-carbonyl)furan-2-yl)ethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 18 - 25 °C

2.1: dimethylsulfide borane complex / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2.2: 18 - 25 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 18 - 25 °C

With dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;