(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

Base Information

Chemical Name:(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene
CAS No.:629615-44-7
Molecular Formula:C₄₄H₅₆O₃Si₂
Molecular Weight:689.098
Hs Code.:

Synonyms:(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

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Chemical Property of (1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

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Technology Process of (1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

There total 9 articles about (1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 943003-71-2
C₅₁H₆₀O₅SSi₂

: 629615-44-7
(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃; for 0.5h;
DOI:10.1002/ejoc.200700068

Reference yield:

: 629615-43-6
(1S,2S,3S,4aR,6S,7R,8aS)-2,3-bis(tert-butyldiphenylsilyloxymethyl)-6,7-epoxydecalin-1-ol

: 629615-44-7
(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 96 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

2.1: 96 percent / nBu₃SnH; AIBN / toluene / 0.5 h / 90 °C

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/ejoc.200700068

Reference yield:

: 943003-63-2
(1RS,2S,3S)-2,3-bis(tert-butyldiphenylsilyloxymethyl)cyclohex-5-en-1-ol

: 629615-44-7
(1aR,2aS,4S,5S,6aR,7aS)-4,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-decahydro-1-oxa-cyclopropa[b]naphthalene

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / MnO₂ / CH₂Cl₂ / 9 h / Heating

2.1: 95 percent / AlCl₃; Me₃Al / toluene / 36 h / 20 °C

3.1: 87 percent / NaBH₄ / CH₂Cl₂; methanol / 16 h / 0 - 20 °C

4.1: 81 percent / mCPBA / CH₂Cl₂ / 2.5 h / -30 - 0 °C

5.1: nBuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

5.2: 96 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

6.1: 96 percent / nBu₃SnH; AIBN / toluene / 0.5 h / 90 °C

With manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; 2,2'-azobis(isobutyronitrile); trimethylaluminum; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; 2.1: Diels-Alder reaction;
DOI:10.1002/ejoc.200700068