C₁₄H₁₂BrCl

Base Information

• Chemical Name: C₁₄H₁₂BrCl
• CAS No.: 20942-30-7
• Molecular Formula: C₁₄H₁₂BrCl
• Molecular Weight: 295.606
• Mol file: 20942-30-7.mol

Synonyms:C₁₄H₁₂BrCl

Chemical Property of C₁₄H₁₂BrCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₂BrCl

There total 7 articles about C₁₄H₁₂BrCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-(3-chlorobenzyl)phenyl)methanol (20942-29-4) → C14H12BrCl (20942-30-7)

Guidance literature:

With hydrogen bromide;

Reference yield:

1-bromomethyl-3-chlorobenzene (766-80-3) → C14H12BrCl (20942-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / ethanol / 3 h / 100 °C

2: sodium tetrahydroborate / methanol; ethyl acetate / 0.5 h / 20 °C

3: phosphorus tribromide / dichloromethane / 0.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; phosphorus tribromide; sodium hydrogencarbonate; In methanol; ethanol; dichloromethane; ethyl acetate; 1: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.1c00275

Reference yield:

2-formylbenzene boronic acid (40138-16-7) → C14H12BrCl (20942-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / ethanol / 3 h / 100 °C

2: sodium tetrahydroborate / methanol; ethyl acetate / 0.5 h / 20 °C

3: phosphorus tribromide / dichloromethane / 0.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; phosphorus tribromide; sodium hydrogencarbonate; In methanol; ethanol; dichloromethane; ethyl acetate; 1: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.1c00275

upstream raw materials:

(2-(3-chlorobenzyl)phenyl)methanol

3-chlorobenzylbenzoic acid

methyl 2-(3-chlorobenzyl)benzoate

o-(3-chloro-benzoyl)-benzoic acid

Downstream raw materials:

<2-(3-Chlorbenzyl)phenyl>acetonitril

<2-(3-Chlorbenzyl)phenyl>essigsaeure

Refernces

• 1、 Fouche,Blondel,Horclois,James,Leger,Poiget. "Research in the field of drugs with psychotropic activity. 11-piperazino 10,11-dihydro (a,d)dibenzo cycloheptene derivatives". . p. 3113 - 3130. Retrieved 2007/10/05.