C₃₆H₅₂F₂N₄O₇

Base Information

• Chemical Name: C₃₆H₅₂F₂N₄O₇
• CAS No.: 1329998-89-1
• Molecular Formula: C₃₆H₅₂F₂N₄O₇
• Molecular Weight: 690.828
• Mol file: 1329998-89-1.mol

Synonyms:C₃₆H₅₂F₂N₄O₇

Chemical Property of C₃₆H₅₂F₂N₄O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₂F₂N₄O₇

There total 12 articles about C₃₆H₅₂F₂N₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ C36H52F2N4O7 (1329998-89-1)

Guidance literature:

Reference yield:

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate (1237495-45-2) + 2-fluoro-2-(3-fluorophenyl)ethanamine hydrochloride (95392-17-9) → C36H52F2N4O7 (1329998-89-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm200411j

Reference yield:

(±)-trans-tert-butyl 3-{[6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl]methyl}-4-hydroxypyrrolidine-1-carboxylate → C36H52F2N4O7 (1329998-89-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 30 h

2: dmap / tetrahydrofuran / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 20 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

5: sodium carbonate / methanol; water / 0.5 h / 35 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 45 °C

7: ozone / dichloromethane / 0.67 h / -78 °C

8: dimethylsulfide / dichloromethane / -78 - 20 °C

9: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 3 h / 20 °C

With 1H-imidazole; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; sodium carbonate; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4: Mitsunobu reaction;

DOI:10.1021/jm200411j

upstream raw materials:

tert-butyl (4,6-dimethylpyridin-2-yl)carbamate

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-hydroxypyrrolidine-1-carboxylate

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate

2-fluoro-2-(3-fluorophenyl)ethanamine hydrochloride