C₁₁H₁₅NO₂

Base Information

• Chemical Name: C₁₁H₁₅NO₂
• CAS No.: 913642-41-8
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 913642-41-8.mol

Synonyms:C₁₁H₁₅NO₂

Chemical Property of C₁₁H₁₅NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₅NO₂

There total 8 articles about C₁₁H₁₅NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(S)-6-((R)-hydroxyphenylmethyl)morpholin-3-one (1005196-91-7) → C11H15NO2 (913642-41-8)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jo701554h

Reference yield:

(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde (130115-07-0) → C11H15NO2 (913642-41-8)

Guidance literature:

Multi-step reaction with 6 steps

1: (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; copper(II) acetate monohydrate / 72 h / 20 °C

2: hydrogenchloride / methanol; water / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr

4: potassium carbonate / 1 h / 0 °C

5: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; potassium tert-butylate; hydrogen; copper(II) acetate monohydrate; potassium carbonate; In tetrahydrofuran; methanol; water; tert-butyl alcohol; 1: |Henry Nitro Aldol Condensation;

DOI:10.1039/c7ob01283g

Reference yield:

(1R,2S)-1-(tert-butyldimethylsilyloxy)-3-nitro-1-phenylpropan-2-ol → C11H15NO2 (913642-41-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; water / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr

3: potassium carbonate / 1 h / 0 °C

4: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; water; tert-butyl alcohol;

DOI:10.1039/c7ob01283g

upstream raw materials:

(S)-6-((R)-hydroxyphenylmethyl)morpholin-3-one

(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde

(1R,2S)-3-amino-1-phenylpropane-1,2-diol

2-chloro-N-((2S,3R)-2,3-dihydroxy-3-phenylpropyl)acetamide

Downstream raw materials:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

(2S)-2-[(R)-(2-ethoxyphenoxy)phenylmethyl]morpholine