(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

Base Information

Chemical Name:(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine
CAS No.:177948-06-0
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

Synonyms:(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

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Chemical Property of (3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

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Technology Process of (3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

There total 4 articles about (3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 56613-80-0
D-2-phenylglycinol

: 177947-76-1
(3R)-1-(tert-butoxycarbonyl)-3-[(methane-sulfonyloxy)methyl]pyrrolidine

: 177948-06-0
(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

Guidance literature:: In toluene; at 150 ℃; for 6h;
DOI:10.1021/jm9805687

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 177948-06-0
(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pearlmans catalyst / methanol; H₂O / 2 h / 2068.59 Torr

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 87 percent / toluene / 6 h / 150 °C

With hydrogen; triethylamine; palladium hydroxide - carbon; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jm9805687

Reference yield:

: 99735-47-4
(3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine

: 177948-06-0
(3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pearlmans catalyst / methanol; H₂O / 2 h / 2068.59 Torr

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 87 percent / toluene / 6 h / 150 °C

With hydrogen; triethylamine; palladium hydroxide - carbon; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jm9805687