11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

Base Information

Chemical Name:11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester
CAS No.:123227-21-4
Molecular Formula:C₂₅H₂₃NO₅S
Molecular Weight:449.527
Hs Code.:

11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenz<b,e>oxepin-2-carboxylic acid methyl ester

Synonyms:11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

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Chemical Property of 11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

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Technology Process of 11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

There total 5 articles about 11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 123227-12-3
11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

: 123227-21-4
11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

Guidance literature:: With boron tribromide; In dichloromethane; at -75 - 20 ℃;
DOI:10.1021/jm00096a016

Reference yield:

: 79669-87-7
methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate

: 123227-21-4
11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol

2: p-toluenesulfonic acid

3: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

4: 99 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 34 percent / boron tribromide / CH₂Cl₂ / -75 - 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; boron tribromide; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00096a016

Reference yield:

: 79669-90-2
methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate

: 123227-21-4
11-<<2-<(2-hydroxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid

2: 96 percent / BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

3: 99 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 34 percent / boron tribromide / CH₂Cl₂ / -75 - 20 °C

With boron trifluoride diethyl etherate; boron tribromide; toluene-4-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00096a016