(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

Base Information

Chemical Name:(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester
CAS No.:292632-49-6
Molecular Formula:C₂₅H₃₁N₅O₆
Molecular Weight:497.551
Hs Code.:

Synonyms:(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

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Chemical Property of (R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

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Technology Process of (R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

There total 4 articles about (R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: C₂₁H₂₄N₄O₅

: 292632-49-6
(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 54h;
DOI:10.1021/jm000130i

Reference yield:

: ethyl 4-[1-methyl-2-(2,4-dimainofuro[2,3-d]pyrimidin-5-yl)ethenyl]benzoate

: 292632-49-6
(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / H₂ / 5percent Pd/C / dimethylformamide; methanol; CHCl₃ / 5.5 h / 20 °C / 2327.23 Torr

2: aq. NaOH / methanol; dimethylsulfoxide / 16 h / 20 °C

3: Et₃N / dimethylformamide / 0.5 h / 0 °C

4: 75 percent / Et₃N / dimethylformamide / 54 h / 0 - 20 °C

With sodium hydroxide; hydrogen; triethylamine; 5percent Pd/C; In methanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Saponification / 3: Esterification / 4: Condensation;
DOI:10.1021/jm000130i

Reference yield:

: 773043-69-9
(R,S)-4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

: 292632-49-6
(R,S)-N-[4-[1-methyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzyl]-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 0.5 h / 0 °C

2: 75 percent / Et₃N / dimethylformamide / 54 h / 0 - 20 °C

With triethylamine; In N,N-dimethyl-formamide; 1: Esterification / 2: Condensation;
DOI:10.1021/jm000130i