(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

Base Information

Chemical Name:(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol
CAS No.:1378433-26-1
Molecular Formula:C₁₇H₂₇BO₄
Molecular Weight:306.21
Hs Code.:

Synonyms:(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

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Chemical Property of (R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

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Technology Process of (R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

There total 3 articles about (R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1440415-08-6
(4R,5S)-3-((S)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propanoyl)-4-methyl-5-phenyloxazolidin-2-one

: 1378433-26-1
(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm400317w

Reference yield:

: 73183-34-3
bis(pinacol)diborane

: 1378433-26-1
(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) chloride; sodium t-butanolate; bis[2-(diphenylphosphino)phenyl] ether / tetrahydrofuran / 0.75 h / 0 °C

1.2: 3 h / 20 °C

2.1: titanium tetrachloride / dichloromethane / 0.17 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere

With lithium borohydride; titanium tetrachloride; bis[2-(diphenylphosphino)phenyl] ether; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm400317w

Reference yield:

: 1378433-24-9
(4R,5S)-4-methyl-5-phenyl-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoyl]-1,3-oxazolidin-2-one

: 1378433-26-1
(R)-3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride / dichloromethane / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere

With lithium borohydride; titanium tetrachloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm400317w