rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

Base Information

Chemical Name:rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate
CAS No.:1262859-35-7
Molecular Formula:C₁₄H₁₆BrF₃O₄
Molecular Weight:385.178
Hs Code.:

Synonyms:rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

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Technology Process of rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

There total 3 articles about rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1262859-33-5
rac-methyl 2-(2-(3-bromophenyl)-2-oxoethoxy)-3,3,3-trifluoro-2-methylpropanoate

: 75-24-1
trimethylaluminum

: 1262859-35-7
rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: rac-methyl 2-(2-(3-bromophenyl)-2-oxoethoxy)-3,3,3-trifluoro-2-methylpropanoate; trimethylaluminum; In n-heptane; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With methyllithium; In diethyl ether; n-heptane; toluene; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02143

Reference yield:

: aqueous NaH₂PO₄

: 1262859-33-5
rac-methyl 2-(2-(3-bromophenyl)-2-oxoethoxy)-3,3,3-trifluoro-2-methylpropanoate

: 1262859-35-7
rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: With methyllithium; AlMe₃; In diethyl ether; n-heptane; ethyl acetate; toluene;

Reference yield:

: 1711-09-7
3-bromobenzoyl chloride

: 1262859-35-7
rac-methyl 2-(2-(3-bromophenyl)-2-hydroxypropoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran; diethyl ether / 2 h / 0 - 25 °C / Inert atmosphere

2.1: tetrakis(trifluoroacetato)rhodium(II) / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere

3.1: toluene; n-heptane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With tetrakis(trifluoroacetato)rhodium(II); triethylamine; In tetrahydrofuran; diethyl ether; n-heptane; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.0c02143