rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

Base Information

Chemical Name:rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate
CAS No.:1262859-39-1
Molecular Formula:C₁₄H₁₇BrF₃NO₃
Molecular Weight:384.193
Hs Code.:

Synonyms:rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

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Technology Process of rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

There total 6 articles about rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1262859-37-9
rac-methyl 2-(2-azido-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

: 1262859-39-1
rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: With hydrogenchloride; indium; In tetrahydrofuran; water; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02143

Reference yield:

: 7440-74-6
indium

: 1262859-37-9
rac-methyl 2-(2-azido-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

: 584-08-7
potassium carbonate

: 1262859-39-1
rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: With hydrogenchloride; In THF-H₂O; ethyl acetate;

Reference yield:

: 7023-79-2
α-diazo-m-bromoacetophenone

: 1262859-39-1
rac-methyl 2-(2-amino-2-(3-bromophenyl)propoxy)-3,3,3-trifluoro-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane

2: methyllithium / AlMe₃ / ethyl acetate; n-heptane; toluene; diethyl ether

3: trimethylsilylazide; BF₃-Et₂O / ethyl acetate; toluene

4: hydrogenchloride / ethyl acetate; THF-H₂O

With hydrogenchloride; BF₃-Et₂O; trimethylsilylazide; methyllithium; AlMe₃; In THF-H₂O; diethyl ether; n-heptane; dichloromethane; ethyl acetate; toluene;