(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester
CAS No.:682743-08-4
Molecular Formula:C₃₅H₄₉N₃O₁₀
Molecular Weight:671.788
Hs Code.:

(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

Synonyms:(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

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Chemical Property of (2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

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Technology Process of (2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

There total 7 articles about (2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 682742-89-8
(2'S)-4-(2'-tert-butoxycarbonylamino-2'-carboxy-ethyl)-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

: 682743-08-4
(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2004.01.011

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 682743-08-4
(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / 2-methyl-propan-2-ol / 24 h / 70 °C

2: 98 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

3: 98 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / 20 °C

4: 98 percent / H₂ / Pd(OH)2/C / ethyl acetate; ethanol / 0.25 h / 20 °C

5: 90 percent / PyBOP; N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; 1: Hantzsch condensation reaction;
DOI:10.1016/j.tet.2004.01.011

Reference yield:

: 14205-43-7
tert-butyl 3-aminocrotonate

: 682743-08-4
(2'S,1''S)-4-[2'-tert-butoxycarbonylamino-2'-(1''-methoxycarbonyl-2''-phenylethylcarbamoyl)-ethyl]-2,6-dimethyl-1-oxido-pyridine-3,5-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / 2-methyl-propan-2-ol / 24 h / 70 °C

2: 98 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

3: 98 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / 20 °C

4: 98 percent / H₂ / Pd(OH)2/C / ethyl acetate; ethanol / 0.25 h / 20 °C

5: 90 percent / PyBOP; N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; 1: Hantzsch condensation reaction;
DOI:10.1016/j.tet.2004.01.011