2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

Base Information

Chemical Name:2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one
CAS No.:189391-45-5
Molecular Formula:C₂₂H₂₁ClN₄O
Molecular Weight:392.888
Hs Code.:

Synonyms:2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

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Chemical Property of 2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

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Technology Process of 2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

There total 10 articles about 2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189393-24-6
2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-phenylethynyl-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

: 189391-45-5
2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; under 2585.7 Torr;
DOI:10.1021/jm9707028

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 189391-45-5
2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 9 steps

1: xylene / 3 h / 105 °C

2: SnCl₂*2H₂O, conc. HCl, AcOH / Ambient temperature

3: (i-Pr)2NEt / tetrahydrofuran / Ambient temperature

4: xylene / 4 h / Heating

5: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, RT, overnight

6: SnCl₂*2H₂O, conc. HCl, AcOH / Ambient temperature

7: 1.) NaNO₂, H₂SO₄, 2.) NaI / 1.) water, 0 deg C, 20 min, 2.) water, from 0 deg C to RT

8: (Ph₃P)2PdCl₂, Et₃N / dimethylformamide / 19 h / 95 °C

9: H₂ / PtO₂ / ethyl acetate / 2585.7 Torr

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; hydrogen; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; tin(ll) chloride; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm9707028

Reference yield:

: 33742-69-7
6-chloro-N-ethyl-3-nitropyridin-2-amine

: 189391-45-5
2-Chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-phenylethyl)-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: SnCl₂*2H₂O, conc. HCl, AcOH / Ambient temperature

2: (i-Pr)2NEt / tetrahydrofuran / Ambient temperature

3: xylene / 4 h / Heating

4: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, RT, overnight

5: SnCl₂*2H₂O, conc. HCl, AcOH / Ambient temperature

6: 1.) NaNO₂, H₂SO₄, 2.) NaI / 1.) water, 0 deg C, 20 min, 2.) water, from 0 deg C to RT

7: (Ph₃P)2PdCl₂, Et₃N / dimethylformamide / 19 h / 95 °C

8: H₂ / PtO₂ / ethyl acetate / 2585.7 Torr

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; hydrogen; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; tin(ll) chloride; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm9707028