33742-69-7

Usage

Uses

Used in Pharmaceutical Synthesis:
6-chloro-N-ethyl-3-nitropyridin-2-amine is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups allow for versatile chemical reactions that can lead to the development of new therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, 6-chloro-N-ethyl-3-nitropyridin-2-amine is used as a building block in the creation of pesticides and other crop protection agents. Its chemical properties make it suitable for the design of compounds that can effectively control pests and diseases in agriculture.
Used in Medicinal Chemistry Research:
6-chloro-N-ethyl-3-nitropyridin-2-amine is utilized as a research compound in medicinal chemistry. Its structure and reactivity are of interest to scientists who are exploring new drug candidates and pathways for the treatment of various diseases and conditions.

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 75-04-7 ethylamine 

Relevant academic research and scientific papers

Synthesis of 2-substituted 3-ethyl-3H-imidazo[4,5-b]pyridines catalyzed by Al3+-exchanged K10 clay as solid acids

A series of imidazopyridine derivatives have been synthesized efficiently via intramolecular cyclization in excellent yields using Al3+- exchanged on K10 montmorillonite clay (Al3+-K10 clay) as a reusable heterogeneous catalyst. To the best of our knowledge, this is the first report to utilize Al3+-K10 as a catalyst for imidazopyridine synthesis. Many functional groups are tolerated during the synthesis of targeted compounds. The catalyst is reused at least five times with a slight decrease in the yield. This catalyst is environmentally benign, cost-effective, and also provides other advantages such as nontoxicity, operational/experimental simplicity, and mild reaction conditions.

Imidazo [4, 5-b] pyridine compounds with biological activity as well as preparation method and application of imidazo [4, 5-b] pyridine compounds

The invention discloses imidazo [4, 5-b] pyridine compounds with biological activity as well as a preparation method and application of the imidazo [4, 5-b] pyridine compounds. The structure of the the imidazo [4, 5-b] pyridine compounds is as shown in a general formula (I), wherein R represents a hydrogen or halogen atom; R1 represents hydrogen or a methyl group; R2 represents hydrogen, a C1-C4 linear or branched alkyl group, or a heterocyclic benzyl group, the heterocyclic ring is a five-membered aromatic heterocyclic ring, and the hydrogen atom on a heterocyclic ring is unsubstituted, optionally substituted by the C1-C4 linear or branched alkyl group, or optionally substituted by the halogen atom; Ar represents a phenyl group, a thienyl group or a thiazolyl group, wherein a hydrogen atom on the ring is unsubstituted, or optionally substituted by a substituent independently selected from a halogen atom, a methoxy group, a methyl group and a halogenated methyl group; X represents O, S, SO or SO2. The compounds shown in the formula (I) have the bactericidal, insecticidal/acaricidal broad-spectrum activity at an amount of 15-5000g of active ingredient per hectare.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Design, Synthesis, and Fungicidal Activity of Novel Imidazo[4,5-b]pyridine Derivatives

A series of novel imidazo[4,5-b]pyridine derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by spectroscopic data NMR, MS, and elemental analysis. Bioassay showed that the compounds exhibited potent fungicidal activities against Erysiphe graminis, Puccinia polysora, and so forth. Particularly, 2-chloro-5-((5-methoxy-2-(2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)thiazole (9b) displayed fungicidal potency against P.?polysora. Its EC50 value: 4.00?mg/L is comparable with that of tebuconazole. The structure–activity relationship for the target compounds is discussed.

Synthesis and Insecticidal Activity of Novel Nitropyridyl-Based Dichloropropene Ethers

Dihalopropene ether insecticides are known for good features such as no cross-resistance to other insecticide classes and safety for mammals. Pyridalyl is the only currently commercialized dichloropropene ether insecticide; however, it contains a trifluoromethyl group, the synthesis of which requires harsh reagents and reaction conditions. To search for novel dihalopropene ethers with unique biological activities but without trifluoromethyl groups, a series of nitropyridyl-based dichloropropene ether analogues were synthesized by reacting nitro-based halopyridine with 2,6-dichloro-4-(3,3-dichloroallyloxy)phenol or 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-hydroxypropyl ether. Bioassay showed that the compounds exhibited potent insecticidal activities against various lepidopteran pests. Particularly, 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-(5-nitro-2-pyridyloxy)propyl ether (8e) was active against major agricultural pests, and its insecticidal potency was comparable to that of Pyridalyl. Besides the trifluoromethyl group in Pyridalyl, a nitro group on the 5-position of the pyridyl ring is also viable for the development of optimal insecticidal activity.

Preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via phosphorus oxychloride-mediated cyclization of aminoureas

The novel preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via the cyclization of (2-aminopyridin-3-yl)urea and (2-aminophenyl)urea substrates in the presence of phosphorus oxychloride is described. This methodology is demonstrated for a range of urea substrates with aminoimidazole products obtained in good yields and with excellent levels of purity.

Non-nucleoside reverse transcriptase inhibitors

Provided are compounds of the general formula I: wherein R2 is selected from the group consisting of H, F, Cl, (C1-4) alkyl, (C3-4) cycloalkyl and CF3; R4 is H or Me; R5 is H, Me or Et, wit

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8- Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild- type and mutant enzymes

Like other nonnucleoside inhibitors of HIV-1 reverse transcriptase, the dipyridodiazepinone nevirapine (Viramune, 1) selects for drug resistant variants of HIV-1, both in cell culture and in patients. In particular, the mutation of residue 181 from tyrosine to cysteine (Y181C) is associated with resistance to most reported nonnucleoside inhibitors. Introduction of an arylethyl substituent at the 8-position of the tricyclic dipyridodiazepinone skeleton confers enhanced potency against Y181C RT. Several analogues of this series display good broad spectrum potency against a panel of mutant enzymes.