N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

Base Information

Chemical Name:N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide
CAS No.:1350440-51-5
Molecular Formula:C₅₀H₅₆N₁₀O₅S
Molecular Weight:909.125
Hs Code.:

N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

Synonyms:N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

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Chemical Property of N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

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Technology Process of N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

There total 4 articles about N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350440-50-4
di-(4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenyl) sulfide

: 4-methyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid

: 1350440-51-5
N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 1350442-00-0
di-(4-hydroxyamino-3-(N-t-butoxycarbonyl-N-methylamino)phenyl) sulfide

: 1350440-51-5
N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 26 h / 55 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350440-51-5
N-[4-{4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio}-2-(N-t-butoxycarbonyl-N-methylamino)phenyl]-4-methyl-2-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzoimidazol-6-yl carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium thioacetate / N,N-dimethyl-formamide / 8.5 h / 180 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 72 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 26 h / 55 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium thioacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;