1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

Base Information

Chemical Name:1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne
CAS No.:885325-36-0
Molecular Formula:C₂₁H₂₁NO
Molecular Weight:303.404
Hs Code.:

Synonyms:1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

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Chemical Property of 1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

Chemical Property:

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Technology Process of 1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

There total 3 articles about 1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 120517-37-5
4-(3-hydroxy-3-methyl-1-butynyl)-1-iodobenzene

: 17573-94-3,752235-18-0
4-ethynyl-N,N-dimethylaniline

: 885325-36-0
1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

Guidance literature:: With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In triethylamine; at 20 ℃;
DOI:10.1016/j.tetlet.2004.07.123

Reference yield:

: 698-70-4
4-Iodo-N,N-dimethylaniline

: 885325-36-0
1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / diethylamine; copper(I) iodide / dichlorobis[triphenylphosphine]palladium

2: sodium hydroxide / toluene / Heating

3: 82 percent / copper(I) iodide; diethylamine / dichlorobis[(triphenyl)phosphine]palladium / 8 h / 20 °C

With sodium hydroxide; copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; 1: Sonogashira reaction / 3: Sonogashira reaction;
DOI:10.1016/j.tet.2006.01.032

Reference yield:

: 56512-48-2
4-(3-methyl-3-hydroxy-1-butynyl)-N,N-dimethylaniline

: 885325-36-0
1-[p-(3-hydroxy-3-methyl-1-butynyl)phenyl]-2-(p-N,N-dimethylaminophenyl)ethyne

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / Heating

2: 82 percent / copper(I) iodide; diethylamine / dichlorobis[(triphenyl)phosphine]palladium / 8 h / 20 °C

With sodium hydroxide; copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; 2: Sonogashira reaction;
DOI:10.1016/j.tet.2006.01.032