Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester
CAS No.:124868-03-7
Molecular Formula:C₁₉H₁₇F₃O₆S
Molecular Weight:430.402
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Suppliers and Price of Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

There total 8 articles about Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 115997-91-6,116050-97-6,124986-92-1,124986-93-2
(2S,3R,4S,5S)-2-(hydroxymethyl)-5-phenyltetrahydrofuran-3,4-diol

: 124868-03-7
Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: With triethylamine; In pyridine; at -15 ℃; for 2h; Yield given;
DOI:10.1246/bcsj.62.2328

Reference yield:

: 1100-88-5
benzyltriphenylphosphonium chloride

: 124868-03-7
Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) THF, hexane, 1 h, RT, 2) THF, hexane, 1 h, RT

2: 81 percent / PhSH, AIBN / benzene / 0.5 h / Heating

3: 93 percent / pyridine / 20 h / 0 °C

4: mCPBA / CH₂Cl₂ / 2.5 h / Heating

5: 1) NaOMe, 2) SiO₂ / 1) MeOH, 2.5 h, RT, 2) CH₂Cl₂, 32 h, RT

6: Et₃N / pyridine / 2 h / -15 °C

With pyridine; n-butyllithium; 2,2'-azobis(isobutyronitrile); sodium methylate; silica gel; thiophenol; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; benzene;
DOI:10.1246/bcsj.62.2328

Reference yield:

: 2,4-O-benzylidene-L-threose

: 124868-03-7
Trifluoro-methanesulfonic acid (4aS,6S,7S,7aR)-2,6-diphenyl-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) THF, hexane, 1 h, RT, 2) THF, hexane, 1 h, RT

2: 81 percent / PhSH, AIBN / benzene / 0.5 h / Heating

3: 93 percent / pyridine / 20 h / 0 °C

4: mCPBA / CH₂Cl₂ / 2.5 h / Heating

5: 1) NaOMe, 2) SiO₂ / 1) MeOH, 2.5 h, RT, 2) CH₂Cl₂, 32 h, RT

6: Et₃N / pyridine / 2 h / -15 °C

With pyridine; n-butyllithium; 2,2'-azobis(isobutyronitrile); sodium methylate; silica gel; thiophenol; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; benzene;
DOI:10.1246/bcsj.62.2328