3-Methoxythiophene-2-carbaldehyde

Base Information

• Chemical Name: 3-Methoxythiophene-2-carbaldehyde
• CAS No.: 35134-07-7
• Molecular Formula: C6H6 O2 S
• Molecular Weight: 142.178
• Hs Code.: 2934999090
• Mol file: 35134-07-7.mol

Synonyms:2-Formyl-3-methoxythiophene;3-Methoxythiophene-2-carboxaldehyde

Chemical Property of 3-Methoxythiophene-2-carbaldehyde

Chemical Property:

• Melting Point: 84℃
• Boiling Point: 255.8±20.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.240±0.06 g/cm3(Predicted)
• LogP: 1.56920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

3-Methoxythiophene-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxythiophene-2-carboxaldehyde is used as a pharmaceutical intermediate.

Technology Process of 3-Methoxythiophene-2-carbaldehyde

There total 7 articles about 3-Methoxythiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

3-methoxy-thiophene (17573-92-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-methoxy-2-thiophenecarboxaldehyde (35134-07-7)

Guidance literature:

With trichlorophosphate; at 0 - 25 ℃; for 1h;

Reference yield: 80.0%

3-hydroxythiophene-2-carboxaldehyde (5118-08-1) + methyl iodide (74-88-4) → 3-methoxy-2-thiophenecarboxaldehyde (35134-07-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 60.0%

3-methoxy-thiophene (17573-92-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-methoxy-2-thiophenecarboxaldehyde (35134-07-7) + 4-methoxy-thiophene-2-carboxaldehyde (98316-32-6)

Guidance literature:

3-methoxy-thiophene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.5012/bkcs.2011.32.3.1063

upstream raw materials:

3-methoxy-thiophene

N,N-dimethyl-formamide

n-butyllithium

3-hydroxythiophene-2-carboxaldehyde

Downstream raw materials:

N-<(3-Methoxy-2-thienyl)methylene>-2,6-dimethylaniline

2-chloro-N-(3-methoxy-2-thenyl)-2',6'-dimethylacetanilide

(3-hydroxythiophen-2-yl)-(4-methoxyphenyl)-methanone

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