tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate
CAS No.:1314097-72-7
Molecular Formula:C₁₇H₂₁F₃N₂O₃
Molecular Weight:358.361
Hs Code.:

Synonyms:tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

There total 1 articles about tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 395-44-8
o-trifluoromethylbenzyl bromide

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 1314097-72-7
tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium tert-butylate; palladium diacetate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.04.029

Reference yield:

: 1314097-72-7
tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

: 3-oxo-5-(3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl)-2,3-dihydropyridazine-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 10 - 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 16 h / 100 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00430

Reference yield:

: 1314097-72-7
tert-butyl 3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

: 4-chloro-5-(3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 10 - 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 16 h / 100 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/acsmedchemlett.9b00430