(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

Base Information

Chemical Name:(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine
CAS No.:160999-36-0
Molecular Formula:C₂₀H₂₆N₄O₂
Molecular Weight:354.452
Hs Code.:

Synonyms:(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

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Chemical Property of (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

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Technology Process of (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

There total 5 articles about (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 82830-36-2
1-Benzyl-5-(chloromethyl)-1H-imidazolium chloride

: 160999-36-0
(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) - 70 deg C, 15 min, 2.) -70 deg C, 6 h; r.t., 1 h;
DOI:10.1002/recl.19941130603

Reference yield:

: 80304-50-3
1-benzyl-5-hydroxymethylimidazole

: 160999-36-0
(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / SOCl₂ / 0.33 h / Heating

2: 84 percent / BuLi / tetrahydrofuran; hexane / 1.) - 70 deg C, 15 min, 2.) -70 deg C, 6 h; r.t., 1 h

With n-butyllithium; thionyl chloride; In tetrahydrofuran; hexane;
DOI:10.1002/recl.19941130603

Reference yield:

: 60293-41-6
N-((E)-3-phenylallylidene)benzylamine

: 160999-36-0
(2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / methanol / 4 h

2: 85 percent / NaIO₄, K₂S₂O₂(OH)4 / dioxane; H₂O / 24 h / 60 °C

3: 99 percent / LiAlH₄ / tetrahydrofuran / 0.25 h

4: 99 percent / SOCl₂ / 0.33 h / Heating

5: 84 percent / BuLi / tetrahydrofuran; hexane / 1.) - 70 deg C, 15 min, 2.) -70 deg C, 6 h; r.t., 1 h

With sodium periodate; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; K₂S₂O₂(OH)4; potassium tert-butylate; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;
DOI:10.1002/recl.19941130603