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80304-50-3

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80304-50-3 Usage

Description

1-Benzyl-5-hydroxymethyl-1H-imidazole is a chemical compound with the molecular formula C11H12N2O. It is a benzyl derivative of imidazole, characterized by its white to off-white solid appearance and solubility in organic solvents such as ethanol, acetone, and dimethyl sulfoxide. 1-BENZYL-5-HYDROXYMETHYL-1H-IMIDAZOLE has garnered interest in various fields due to its potential applications in pharmaceutical research and organic synthesis.

Uses

Used in Pharmaceutical Research:
1-Benzyl-5-hydroxymethyl-1H-imidazole is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block for the development of new drugs with diverse therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-benzyl-5-hydroxymethyl-1H-imidazole serves as a versatile reagent and catalyst. Its ability to participate in various chemical reactions, such as condensation, cyclization, and substitution, makes it a useful component in the preparation of complex organic molecules.
Used in Antifungal and Antibacterial Applications:
1-Benzyl-5-hydroxymethyl-1H-imidazole has been studied for its potential use as an antifungal and antibacterial agent. Its ability to inhibit the growth of various pathogenic microorganisms makes it a promising candidate for the development of new antimicrobial agents to combat drug-resistant infections.
Used in Neurological Disorder Treatment:
1-BENZYL-5-HYDROXYMETHYL-1H-IMIDAZOLE has been investigated for its potential role in the treatment of neurological disorders. Its ability to modulate specific biological pathways and target cellular mechanisms involved in neurodegenerative diseases positions it as a potential therapeutic agent for conditions such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used in Anticancer Applications:
1-Benzyl-5-hydroxymethyl-1H-imidazole has also been explored as a potential anticancer agent. Its capacity to interfere with cancer cell growth, proliferation, and survival pathways suggests its potential use in the development of novel cancer therapies, either as a standalone treatment or in combination with existing chemotherapeutic drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 80304-50-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,3,0 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 80304-50:
(7*8)+(6*0)+(5*3)+(4*0)+(3*4)+(2*5)+(1*0)=93
93 % 10 = 3
So 80304-50-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O/c14-8-11-6-12-9-13(11)7-10-4-2-1-3-5-10/h1-6,9,14H,7-8H2

80304-50-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-benzylimidazol-4-yl)methanol

1.2 Other means of identification

Product number -
Other names N1-Benzyl-5-hydroxymethylimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80304-50-3 SDS

80304-50-3Relevant articles and documents

A Continuous-Flow Method for the Desulfurization of Substituted Thioimidazoles Applied to the Synthesis of Etomidate Derivatives

Baumann, Marcus,Baxendale, Ian R.

, p. 6518 - 6524 (2017/12/02)

A simple yet robust flow set-up for the efficient desulfurization of a series of thioimidazoles is presented, which generates the corresponding imidazole derivatives in high yields. The strategic choice of peristaltic over piston pumps allowed reliable delivery of the heterogeneous stream of the thioimidazole substrate into a T-piece where it reacted with NaNO2 in the presence of acetic acid. This approach enabled the controlled and safe formation of the reactive nitrosonium species without uncontrolled exposure to hazardous nitrous oxide by-products as observed in related batch protocols. The value of the resulting imidazole products was further demonstrated by their conversion into various esters representing new derivatives of the known analgesic etomidate through an efficient one-pot Corey–Gilman–Ganem oxidation procedure.

AZOLE HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE

-

, (2014/05/20)

The present invention relates to the filed of pharmarcutical chemistry, and in particular, to a novel class of azole compounds represented by general formula (I), (II) or (III) amd a preparation method thereof, a pharmarcutical composition with the compounds as active components, and a use of the azole compounds and the pharmarcutical composition in the preparation of a medicament for treatment of diseases associated with Lp-PLA2 enzyme activities, wherein each substituent is as deinfed in the specifictaion.

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Ohkanda, Junko,Strickland, Corey L.,Blaskovich, Michelle A.,Carrico, Dora,Lockman, Jeffrey W.,Vogt, Andreas,Bucher, Cynthia J.,Sun, Jiazhi,Qian, Yimin,Knowles, David,Pusateri, Erin E.,Sebti, Said M.,Hamilton, Andrew D.

, p. 482 - 492 (2008/02/04)

A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that of the extended CVIM tetrapeptide,

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