{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid

Base Information

• Chemical Name: {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid
• CAS No.: 565460-57-3
• Molecular Formula: C₁₆H₁₂Cl₂N₂O₅S
• Molecular Weight: 415.254
• Mol file: 565460-57-3.mol

Synonyms:{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid

Chemical Property of {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid

There total 6 articles about {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate (565460-56-2) → {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid (565460-57-3)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/ja0353457

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid (565460-57-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaHCO₃ / methanol / 48 h / Heating

1.2: 81 percent / HCl / 20 °C / pH 4

2.1: 98 percent / H₂ / Pd/C / ethanol / 48 h / 2844.31 Torr

3.1: 49 percent / pyridine / 20 °C

4.1: 82 percent / aq. HCl / Heating

With pyridine; hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/ja0353457

Reference yield:

dimethyl (2R)-2-(2-nitrophenylamino)butanedioate (565460-54-0) → {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid (565460-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / Pd/C / ethanol / 48 h / 2844.31 Torr

2: 49 percent / pyridine / 20 °C

3: 82 percent / aq. HCl / Heating

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja0353457

upstream raw materials:

methyl {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

3,4-dichlorobenzenesulphonyl chloride

ortho-nitrofluorobenzene

methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

Downstream raw materials:

C₂₆H₂₃Cl₂N₃O₆S

C₃₁H₃₂Cl₂N₄O₅S

C₃₂H₃₄Cl₂N₄O₄S

N-[2-(4-cyanophenyl)ethyl]-2-{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetamide