ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

Base Information

Chemical Name:ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate
CAS No.:1309953-51-2
Molecular Formula:C₃₉H₄₂O₆
Molecular Weight:606.759
Hs Code.:

Synonyms:ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

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Chemical Property of ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

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Technology Process of ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

There total 10 articles about ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1309953-49-8
ethyl 2-(3,5-bis(benzyloxy)-2-(hex-5-enoyl)phenyl)acetate

: 123484-13-9
(S)-((but-3-en-2-yloxy)methyl)benzene

: 1309953-51-2
ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol2011117

Reference yield:

: 1309953-47-6
2,4-bis(benzyloxy)-6-(2,2-dimethoxyethyl)benzaldehyde

: 1309953-51-2
ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0.17 h / 0 °C / Inert atmosphere

2.1: Jones reagent / acetone / 2 h / 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; Jones reagent; caesium carbonate; magnesium; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol2011117

Reference yield:

: 1309953-46-5
methyl 2,4-bis(benzyloxy)-6-(2,2-dimethoxyethyl)benzoate

: 1309953-51-2
ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 0.5 h / -78 - 20 °C / Inert atmosphere

2.1: tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere; Molecular sieve

3.1: magnesium / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 0.17 h / 0 °C / Inert atmosphere

4.1: Jones reagent / acetone / 2 h / 0 - 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; Jones reagent; tetra-n-propylammonium perruthenate.; diisobutylaluminium hydride; caesium carbonate; magnesium; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol2011117