tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

• Chemical Name: tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate
• CAS No.: 1225276-05-0
• Molecular Formula: C₂₀H₂₆F₃NO₄
• Molecular Weight: 401.426
• Mol file: 1225276-05-0.mol

Synonyms:tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property of tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

There total 1 articles about tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3-(trifluoromethoxy)benzene (2252-44-0) + tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate (1225276-05-0)

Guidance literature:

1-bromo-3-(trifluoromethoxy)benzene; With TurboGrignard; In tetrahydrofuran; at -5 - 20 ℃; Inert atmosphere;

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate; In tetrahydrofuran; at 0 ℃; for 1.5h;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate (1225276-05-0) → tert-butyl 2-fluoro-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate (1225276-83-4)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 2h;

Reference yield:

tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate (1225276-05-0) → 2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane hydrochloride (1225276-06-1)

Guidance literature:

tert-butyl 2-hydroxy-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate; With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; at -15 ℃; for 1.5h;

With sodium hydrogencarbonate; In dichloromethane;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

upstream raw materials:

1-bromo-3-(trifluoromethoxy)benzene

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

Downstream raw materials:

tert-butyl 2-fluoro-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxylate

2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane hydrochloride