203661-69-2

Basic information

• Product Name: tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
• Synonyms: tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate;7-Boc-2-oxo-7-azaspiro[3....;7-Boc-2-oxo-7-azaspiro[3.5]nonane;2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one;2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester;2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester
• CAS NO: 203661-69-2
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239
• Mol File: 203661-69-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 55-56℃
• Boiling Point: 349℃
• Flash Point: 165℃
• Appearance: /
• Density: 1.12
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.80±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate(203661-69-2)
• EPA Substance Registry System: tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate(203661-69-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 203661-69-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 76-02-8 trifluoroacetyl chloride 
• 396653-31-9 tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 

Downstream Products

• 1421270-68-9 C₂₄H₂₆Cl₂FN₅O 
• 1421270-73-6 (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate 
• 1239319-83-5 tert-Butyl 2-(4-nitrophenoxycarbonylamino)-7-azaspiro[3.5]nonane-7-carboxylate 
• 1239319-82-4 2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 1346515-32-9 C₂₁H₂₄F₃N₃O₂ 
• 1346515-31-8 C₂₁H₂₄F₃N₃O₃ 
• 1225275-48-8 N-(3,4-dimethylisoxazol-5-yl)-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxamide 
• 1346515-30-7 C₂₁H₂₄F₃N₃O₃ 
• 1346515-29-4 C₂₁H₂₇N₃O₃ 

Relevant articles and documents

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Synthetic methods of 7-azaspiro[3,5]-nonane-2-ol and hydrochloride compound thereof

The invention discloses 7-azaspiro-[3,5]-nonane-2-ol and a hydrochloride compound thereof. Concretely, N-Boc-4-piperidone is used as a raw material, a wittig reaction is carried out in order to prepare N-Boc-4-methylenepiperidine, zinc/copper is used for catalysis of trichloroacetyl chloride in order to carry out [2+2] cyclisation for preparing N-Boc-7-azaspiro ketone; the azaspiro ketone intermediate is reduced into N-Boc-7-azaspiro-ol by sodium borohydride at a room temperature, and finally 2mol/L hydrochloric acid-ethyl acetate is used for removing Boc in order to prepare a target product hydrochloride whose purity reaches 98%. The product has the advantages of economical and easily available reagents and raw materials which are needed, simple operation, and high product purity; and the product is suitable for batch production.