4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

Base Information

Chemical Name:4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester
CAS No.:914478-96-9
Molecular Formula:C₂₅H₁₉Cl₂N₃O₅
Molecular Weight:512.349
Hs Code.:

Synonyms:4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

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Chemical Property of 4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

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Technology Process of 4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

There total 3 articles about 4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 165663-10-5
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione

: 30806-83-8
p-ethoxycarbonylphenyl isocyanate

: 914478-96-9
4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

Guidance literature:: With triethylamine; In toluene; at 100 ℃; for 12h;
DOI:10.1021/jm060499t

Reference yield:

: 953-14-0
N,N'-bis(4-chlorophenyl)hydrazine

: 914478-96-9
4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaOEt / ethanol / 50 °C

1.2: ethanol / 1.5 h / 50 - 150 °C

1.3: 3 h / 200 °C

2.1: 85 percent / Et₃N / toluene / 12 h / 100 °C

With sodium ethanolate; triethylamine; In ethanol; toluene;
DOI:10.1021/jm060499t

Reference yield:

: 21650-51-1,30926-04-6,1602-00-2
(E)-bis(4-chlorophenyl)diazene

: 914478-96-9
4-(1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl)aminobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5.49 g / aq. NH₄Cl; zinc / acetone / 5 h / 20 °C

2.1: NaOEt / ethanol / 50 °C

2.2: ethanol / 1.5 h / 50 - 150 °C

2.3: 3 h / 200 °C

3.1: 85 percent / Et₃N / toluene / 12 h / 100 °C

With sodium ethanolate; ammonium chloride; triethylamine; zinc; In ethanol; acetone; toluene;
DOI:10.1021/jm060499t