1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione

Base Information

Chemical Name:1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione
CAS No.:165663-10-5
Molecular Formula:C15H10Cl2N2O2
Molecular Weight:321.163
Hs Code.:
ChEMBL ID:CHEMBL274639
DSSTox Substance ID:DTXSID10582084
Wikidata:Q82473406
Mol file:165663-10-5.mol

Synonyms:1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione;165663-10-5;DTXSID10582084;A902426

Suppliers and Price of 1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:320.0119330
Heavy Atom Count:21
Complexity:378

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)N(N(C1=O)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl

Technology Process of 1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione

There total 5 articles about 1,2-Bis(4-chlorophenyl)pyrazolidine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 953-14-0
N,N'-bis(4-chlorophenyl)hydrazine

: 105-53-3
diethyl malonate

: 165663-10-5
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione

Guidance literature:: With sodium ethanolate; for 0.0333333h; microwave irradiation;
DOI:10.1016/j.bmcl.2005.03.058

Reference yield:

: 21650-51-1,30926-04-6,1602-00-2
(E)-bis(4-chlorophenyl)diazene

: 165663-10-5
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5.49 g / aq. NH₄Cl; zinc / acetone / 5 h / 20 °C

2.1: NaOEt / ethanol / 50 °C

2.2: ethanol / 1.5 h / 50 - 150 °C

2.3: 3 h / 200 °C

With sodium ethanolate; ammonium chloride; zinc; In ethanol; acetone;
DOI:10.1021/jm060499t

Reference yield:

: 106-47-8
4-chloro-aniline

: 165663-10-5
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: MnO₂ / benzene / 1 h / Heating

2: Zn; NH₄Cl / acetone / 1 h

3: 95 percent / NaOEt / 0.03 h / microwave irradiation

With manganese(IV) oxide; sodium ethanolate; ammonium chloride; zinc; In acetone; benzene;
DOI:10.1016/j.bmcl.2005.03.058