2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Base Information

Chemical Name:2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide
CAS No.:174180-87-1
Molecular Formula:C₃₉H₃₈FN₅O₅
Molecular Weight:675.76
Hs Code.:

2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Synonyms:2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

There total 10 articles about 2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119-75-5
2-nitro-N-phenylaniline

: 174180-87-1
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 110.6 g / toluene / 2 h / 80 °C

2: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

3: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

5: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1021/jm970265x

Reference yield:

: 174181-40-9
N-(2-nitrophenyl)-N-phenylmalonamic acid methyl ester

: 174180-87-1
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

2: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

4: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm970265x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174180-87-1
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-(4-fluoro-phenyl)-N-isopropyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 53.4 g / DMAP, Et₃N / acetonitrile / 3 h / Ambient temperature

2: 60 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

3: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With dmap; N-Bromosuccinimide; Perbenzoic acid; sodium hexamethyldisilazane; sodium hydride; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm970265x